吖啶黄
- CAS号:8048-52-0
- 英文名:ACRIFLAVINE
- 中文名:吖啶黄
- CBNumber:CB2225391
- 分子式:C27H25ClN6
- 分子量:468.98
- MOL File:8048-52-0.mol
- 熔点 :179-181 °C
- 沸点 :612.69°C (rough estimate)
- 密度 :1.0933 (rough estimate)
- 折射率 :1.6000 (estimate)
- 储存条件 :Store at -20°C
- 溶解度 :H2O: soluble0.33g/mL (lit.)(lit.)
- 形态 :Powder
- 颜色 :Deep orange to brownish-red
- Merck :14,123
- CAS 数据库 :8048-52-0(CAS DataBase Reference)
- EPA化学物质信息 :Xanthacridinum (8048-52-0)
- 危险品标志 :Xn,N
- 危险类别码 :22-37/38-41-50/53-20/21/22-50-36/37/38
- 安全说明 :26-39-60-61-36-37/39-29-36/37/39
- 危险品运输编号 :UN 3077 9/PG 3
- WGK Germany :3
- RTECS号 :AR9660000
- 海关编码 :38249064
吖啶黄性质、用途与生产工艺
- 生物活性 Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。
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体外研究
Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells.
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体内研究
Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis.
- 用途 生化研究
- 更新日期:2024/11/11
- 产品编号:XW80485202
- 产品名称:吖啶黄素 acriflavine;3,6-diamino-10-methylacridinium chloride mixture with 3,6-diaminoacridine(proflavine);euflavine
- CAS编号:8048-52-0
- 包装:25G
- 价格:483元
- 更新日期:2024/11/11
- 产品编号:XW80485201
- 产品名称:吖啶黄素 acriflavine;3,6-diamino-10-methylacridinium chloride mixture with 3,6-diaminoacridine(proflavine);euflavine
- CAS编号:8048-52-0
- 包装:5G
- 价格:114元
- 公司名称:Utraco Holland B.V.
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- 国家:荷兰
- 产品数:159
- 优势度:58