盐酸阿柔比星
- CAS号:75443-99-1
- 英文名:ACLARUBICIN HYDROCHLORIDE
- 中文名:盐酸阿柔比星
- CBNumber:CB2189954
- 分子式:C42H54ClNO15
- 分子量:848.33
- MOL File:75443-99-1.mol
- 熔点 :151-153℃
- 沸点 :898℃
- 闪点 :>110°(230°F)
- 储存条件 :2-8°C
- 溶解度 :Soluble in DMSO or DMF at 25mg/ml
- 形态 :Solid
- 颜色 :Light yellow to yellow
- 危险品标志 :T
- 危险类别码 :23/24/25
- 安全说明 :36/37/39-45
- 危险品运输编号 :3249
- RTECS号 :QI9283500
- 危险等级 :6.1(a)
- 包装类别 :II
盐酸阿柔比星 化学药品说明书
注射用盐酸阿柔比星
盐酸阿柔比星性质、用途与生产工艺
- 生物活性 Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的 CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效蒽环类化疗试剂用于血癌和实体肿瘤的相关研究。
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靶点
20S proteasome.
Topoisomerase I and II. -
体外研究
Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ . Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .
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体内研究
Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD 50 (76.5 mg/kg) is about twice the iv LD 50 (35.6 mg/kg) in mice [4 .
Aclacinomycin A (0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model [4 .
Animal Model: DBA/2, CDF 1 (BALB/c×DBA/2) mice with Leukemia P-388 [4 . Dosage: 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg. Administration: Intraperitoneal administration daily for 10 days starting 3 hr after transplantation. Result: Inhibited tumor growth.
- 更新日期：2023/01/06
- 产品编号：HY-N2306A
- 产品名称：盐酸阿柔比星 Aclacinomycin A hydrochloride
- CAS编号：75443-99-1
- 包装：5mg
- 价格：2800元
- 更新日期：2023/01/06
- 产品编号：HY-N2306A
- 产品名称：盐酸阿柔比星 Aclacinomycin A hydrochloride
- CAS编号：75443-99-1
- 包装：10 mM * 1 mLin DMSO
- 价格：4479元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
