苦木素

生物活性靶点体外研究体内研究苦木素试剂级价格

苦木素

CAS号:76-78-8
英文名:QUASSIN
中文名:苦木素
CBNumber:CB2147903
分子式:C22H28O6
分子量:388.45
MOL File:76-78-8.mol

苦木素化学性质

熔点 :222°
比旋光度 :D20 +34.5° (c = 5.09 in CHCl3)
沸点 :586.3±50.0 °C(Predicted)
密度 :1.23±0.1 g/cm3(Predicted)
储存条件 :-20°C Freezer, Under inert atmosphere
溶解度 :Chloroform (Slightly), Methanol (Slightly)
形态 :Solid
颜色 :White to Off-White
旋光性 (optical activity) :+34.520 (c 5.09, CHCl3)
LogP :2.220 (est)
EPA化学物质信息 :Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- (76-78-8)

苦木素性质、用途与生产工艺

生物活性 Quassin (Nigakilactone D) 是一种从 Quassia amara 的茎皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum，IC50 为 0.15 μM。Quassin 具有可逆的抗生育能力，抗雌激素和抗疟原虫活性。
靶点

IC50: 0.15 μM ( P. falciparum )
体外研究

Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion.

体内研究

Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats.

Animal Model:	35 females albino rats (150-170 g)
Dosage:	0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg
Administration:	Oral administration; daily; for 60 days
Result:	There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats.

用途 Quassin is a naturally occurring extract from quassia trees and is used in traditional chinese medicine for it鈥檚 antiulcerogenic properties. Quassin have also been used as an additive in soft drinks.