吡咯他尼杂质A

生物活性体内研究吡咯他尼杂质A 试剂级价格

吡咯他尼杂质A

CAS号:57-64-7
英文名:PHYSOSTIGMINE SALICYLATE
中文名:吡咯他尼杂质A
CBNumber:CB2146890
分子式:C22H27N3O5
分子量:413.47
MOL File:57-64-7.mol

吡咯他尼杂质A化学性质

熔点 :181-183 °C
储存条件 :-20°C
溶解度 :DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
酸度系数(pKa) :pKa 1.96/8.08(H2O,t =15) (Uncertain)
形态 :Solid
颜色 :White to yellow
Merck :7384
BRN :3900576
InChIKey :HZOTZTANVBDFOF-DPKVYHSMNA-N
SMILES :C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r|
CAS 数据库 :57-64-7(CAS DataBase Reference)
EPA化学物质信息 :Physostigmine salicylate (57-64-7)

安全信息

危险品标志 :T+
危险类别码 :26/28
安全说明 :25-45
危险品运输编号 :UN 1544 6.1/PG 1
WGK Germany :3
RTECS号 :TJ2450000
危险等级 :6.1(a)
包装类别 :II
海关编码 :2939800000
毒性 :LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)

吡咯他尼杂质A 化学药品说明书

水杨酸毒扁豆碱|药物应用信息
水杨酸毒扁豆碱注射液

吡咯他尼杂质A性质、用途与生产工艺

生物活性 Physostigmine salicylate (Eserine salicylate) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。Physostigmine salicylate 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine salicylate 能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine salicylate 也是抗胆碱能中毒的解毒剂。

体内研究

Physostigmine salicylate (Eserine salicylate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.
Physostigmine salicylate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.

Animal Model:	Heterozygous transgenic mice (Tg(+) mice)
Dosage:	0.03, 0.1, and 0.3 mg/kg
Administration:	SC; daily for 6 weeks
Result:	Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.