ChemicalBook CAS数据库列表 3,4,5,4'-四甲氧基二苯乙烯
3,4,5,4'-四甲氧基二苯乙烯
- CAS号:134029-62-2
- 英文名:3,4,5,4'-TETRAMETHOXYSTILBENE
- 中文名:3,4,5,4'-四甲氧基二苯乙烯
- CBNumber:CB21441938
- 分子式:C18H20O4
- 分子量:300.349
- MOL File:134029-62-2.mol
3,4,5,4'-四甲氧基二苯乙烯化学性质
- 熔点 :157-159℃
- 沸点 :444.0±40.0 °C(Predicted)
- 密度 :1.117
- 储存条件 :2-8°C
- 溶解度 :DMSO: soluble5mg/mL, clear (warmed)
- 形态 :powder
- 颜色 :white to beige
安全信息
- WGK Germany :3
3,4,5,4'-四甲氧基二苯乙烯性质、用途与生产工艺
- 生物活性 DMU-212 是一种白藜芦醇 (HY-16561) 甲基化衍生物，具有抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。DMU-212 通过诱导凋亡 (apoptosis) 和激活 ERK1/2 蛋白导致有丝分裂停止。DMU-212 具有口服活性。
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体外研究
DMU-212 (0.3125-40 μM) inhibits growth of A375, MeWo, Bro and M5 cells human melanoma cells.
DMU-212 (30-50 μM; 24 hours) induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces G2/M arrest and apoptosis in cancer cells.
DMU-212 induces mitotic arrest, apoptosis and activation of ERK1/2 protein.
Cell Proliferation Assay
Cell Line: A375 cells, MeWo cells, M5 cells, Bro cells Concentration: 0.3125 μM, 0,625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time: 96 hours Result: Inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC 50 =0.5 μM for A375 and Bro and IC 50 = 1.25 μM for MeWo and M5 cells). Cell Cycle Analysis
Cell Line: A375 cells Concentration: 20 μM, 30 μM, 50 μM Incubation Time: 24 hours Result: Caused a marked increase in the levels of p21, p53 and cyclin B1 proteins with a concomitant decrease in the levels of cyclin A2. Western Blot Analysis
Cell Line: A375 cells Concentration: 20 μM, 30 μM, 50 μM Incubation Time: 24 hours Result: Significant upregulation of Bax, caspase 3 and caspase 9 protein levels, while the levels of the anti-apoptotic protein Bcl-2 were decreased. -
体内研究
DMU-212 (50 mg/kg; i.g.; three times a week; for 14 days) inhibits tumor growth in xenograft model of human ovarian cancer.
Animal Model: 6-weeks-old SCID female mice (20-24 g), with ovarian cancer xenografts Dosage: 50 mg/kg Administration: Oral gavage, three times a week, for 14 days Result: Lower tumor burden.
3,4,5,4'-四甲氧基二苯乙烯上下游产品信息
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3,4,5,4'-四甲氧基二苯乙烯 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-137977
- 产品名称：DMU-212
- CAS编号：
- 包装：1 mg
- 价格：248元
- 更新日期：2024/11/08
- 产品编号：HY-137977
- 产品名称：3,4,5,4'-四甲氧基二苯乙烯 DMU-212
- CAS编号：134029-62-2
- 包装：10mM * 1mLin DMSO
- 价格：550元
3,4,5,4'-四甲氧基二苯乙烯生产厂家
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32161
- 优势度：58
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：52924
- 优势度：58
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：
- 电子邮件：support@targetmol.com
- 国家：美国
- 产品数：38631
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
- 公司名称：SIGMAALDRICH
- 联系电话：--
- 电子邮件：
- 国家：美国
- 产品数：6773
- 优势度：87
- 公司名称：International Laboratory Limited
- 联系电话：--
- 电子邮件：admin@intlab.org
- 国家：美国
- 产品数：5356
- 优势度：50
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