3,4,5,4'-四甲氧基二苯乙烯
中文名称:3,4,5,4'-四甲氧基二苯乙烯
英文名称:3,4,5,4'-TETRAMETHOXYSTILBENE
CAS号:134029-62-2
分子式:C18H20O4
分子量:300.349
EINECS号:1312995-182-4
Mol文件:134029-62-2.mol
3,4,5,4'-四甲氧基二苯乙烯 性质
| 熔点 | 157-159℃ |
|---|---|
| 沸点 | 444.0±40.0 °C(Predicted) |
| 密度 | 1.117 |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：可溶5mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
3,4,5,4'-四甲氧基二苯乙烯 用途与合成方法
DMU-212 是一种白藜芦醇 (HY-16561) 甲基化衍生物，具有抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。DMU-212 通过诱导凋亡 (apoptosis) 和激活 ERK1/2 蛋白导致有丝分裂停止。DMU-212 具有口服活性。
DMU-212 (0.3125-40 μM) inhibits growth of A375, MeWo, Bro and M5 cells human melanoma cells.
DMU-212 (30-50 μM; 24 hours) induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces G2/M arrest and apoptosis in cancer cells.
DMU-212 induces mitotic arrest, apoptosis and activation of ERK1/2 protein.
Cell Proliferation Assay
| Cell Line: | A375 cells, MeWo cells, M5 cells, Bro cells |
| Concentration: | 0.3125 μM, 0,625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM |
| Incubation Time: | 96 hours |
| Result: | Inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC 50 =0.5 μM for A375 and Bro and IC 50 = 1.25 μM for MeWo and M5 cells). |
Cell Cycle Analysis
| Cell Line: | A375 cells |
| Concentration: | 20 μM, 30 μM, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Caused a marked increase in the levels of p21, p53 and cyclin B1 proteins with a concomitant decrease in the levels of cyclin A2. |
Western Blot Analysis
| Cell Line: | A375 cells |
| Concentration: | 20 μM, 30 μM, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Significant upregulation of Bax, caspase 3 and caspase 9 protein levels, while the levels of the anti-apoptotic protein Bcl-2 were decreased. |
DMU-212 (50 mg/kg; i.g.; three times a week; for 14 days) inhibits tumor growth in xenograft model of human ovarian cancer.
| Animal Model: | 6-weeks-old SCID female mice (20-24 g), with ovarian cancer xenografts |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage, three times a week, for 14 days |
| Result: | Lower tumor burden. |
3,4,5,4'-四甲氧基二苯乙烯 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-02-05 | HY-137977 | 3,4,5,4'-四甲氧基二苯乙烯 | 134029-62-2 | 1 mg | 248 |
| 2025-02-05 | HY-137977 | 3,4,5,4'-四甲氧基二苯乙烯 | 134029-62-2 | 10mM * 1mLin DMSO | 550 |
3,4,5,4'-四甲氧基二苯乙烯供应商 更多
艾科试剂
联系电话：4008-755-333 18080918076
产品介绍：
中文名称：3,4,5,4'-四甲氧基二苯乙烯
CAS：134029-62-2
纯度：HPLC;GR;AR;CP
包装信息：5g;25g;100g;500g
备注：试剂级
成都零六生物科技有限公司
联系电话：400-1166-196 13458535857
产品介绍：
中文名称：3,4,5,4'-四甲氧基二苯乙烯
英文名称：3,4,5,4'-TETRAMETHOXYSTILBENE
CAS：134029-62-2
纯度：99% HPLC
包装信息：10g;50g;100g;500g;1kg;5kg;25kg
上海威芬奇医药科技有限公司
联系电话： 13817485796
产品介绍：
英文名称：3,4,5,4'-Tetramethoxystilbene
CAS：134029-62-2
纯度：0.97
包装信息：1G;5G;10g,25g,100g,500g
备注：品牌：上海威芬奇/生产商
天津凯利奇生物科技有限公司
联系电话： 15076683720
产品介绍：
英文名称：DMU-212
CAS：134029-62-2
纯度：大于98%
包装信息：1g,5g,10g,25g根据客户需要分装
备注：Not For Human Use, Lab Use Only.
最新发布供应信息
134029-62-2DMU-212
上海嘉定区澄浏公路52号
2025-02-06
化合物 DMU-212|T36674|TargetMol
TargetMol中国（陶术生物）
2024-12-12
