2-羟基乳清酸

生物活性体外研究体内研究 2-羟基乳清酸试剂级价格

2-羟基乳清酸

CAS号:56472-29-8
英文名:2-HYDROXYOLEICACID
中文名:2-羟基乳清酸
CBNumber:CB21403596
分子式:C18H34O3
分子量:298.46
MOL File:56472-29-8.mol

2-羟基乳清酸化学性质

熔点 :47-50oC
储存条件 :room temp
溶解度 :DMSO: >20mg/mL
形态 :Solid
颜色 :white to tan

安全信息

危险品标志 :Xi
危险类别码 :41
安全说明 :26-39
WGK Germany :3

2-羟基乳清酸性质、用途与生产工艺

生物活性 Minerval (2-Hydroxyoleic acid) 是一种合成油酸 (OA) 衍生物，能与质膜结合改变脂质组织。Minerval 具有抗肿瘤作用。

体外研究

Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC ₅₀ of ~40 μM.
Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis.

Cell Viability Assay

Cell Line:	Jurkat cells
Concentration:	25 μM, 50 μM, 75 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Impaired Jurkat cell growth in a time- and concentration-dependent manner.

Western Blot Analysis

Cell Line:	Jurkat cells
Concentration:	25 μM, 50 μM
Incubation Time:	72 hours
Result:	Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.

体内研究

Minerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells.

Animal Model:	6-week-old nude male mice (Jurkat cells xenograft model)
Dosage:	600 mg/kg
Administration:	Oral administration; daily; for 21 days
Result:	Markedly and significantly inhibited tumour growth.