羟保松

生物活性靶点体外研究体内研究羟保松试剂级价格

羟保松

CAS号:129-20-4
英文名:OXYPHENYL BUTAZONE
中文名:羟保松
CBNumber:CB2133346
分子式:C19H20N2O3
分子量:324.37
MOL File:129-20-4.mol

羟保松化学性质

熔点 :109-111°C
沸点 :462.71°C (rough estimate)
密度 :1.2118 (rough estimate)
折射率 :1.6140 (estimate)
储存条件 :-20°C
溶解度 :DMSO: soluble10mg/mL, clear
酸度系数(pKa) :pKa 4.7/10.0±0.2(H2O,t =25,Iundefined) (Uncertain)
形态 :powder
颜色 :white to brown
水溶解性 :20mg/L(room temperature)
稳定性 :Hygroscopic
CAS 数据库 :129-20-4(CAS DataBase Reference)
(IARC)致癌物分类 :3 (Vol. 13, Sup 7) 1987
EPA化学物质信息 :3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl- (129-20-4)

安全信息

危险品标志 :Xn,N
危险类别码 :22-50
安全说明 :61
危险品运输编号 :UN 3077 9 / PGIII
WGK Germany :3
毒害物质数据 :129-20-4(Hazardous Substances Data)

羟保松化学药品说明书

羟布宗|药物应用信息

羟保松性质、用途与生产工艺

生物活性 Oxyphenbutazone 是一种苯丁酮衍生物，具有抗炎作用。Oxyphenbutazone 是一种非选择性的 COX 抑制剂。Oxyphenbutazone 能选择性地杀死不复制的结核分枝杆菌。
靶点

COX

体外研究

Oxyphenbutazone enhances the anticancer efficiency of methotrexate (MTX) in Hep3B cells.
Oxyphenbutazone (2.5 -7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells.
Oxyphenbutazone exhibits reparative effects in the hepatocytes.

Cell Cytotoxicity Assay

Cell Line:	Hep3B cells
Concentration:	2.5 µM, 5 µM, 7.5 µM
Incubation Time:	48 hours
Result:	Enhanced the cytotoxicity of MTX.

体内研究

Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).

Animal Model:	5–6 weeks Wistar strain albino male rats (150–220 g)
Dosage:	70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week)
Administration:	Oral administration; once a week; in two divided doses; for 13 weeks
Result:	Exerted potential anticancer activity in rats when co-treatment with MTX.