育亨宾碱
- CAS号:6211-32-1
- 英文名:Rauwolscine hydrochloride
- 中文名:育亨宾碱
- CBNumber:CB1684795
- 分子式:C21H27ClN2O3
- 分子量:390.9
- MOL File:6211-32-1.mol
- 熔点 :270-280°C
- 储存条件 :Store at RT
- 溶解度 :H2O: soluble
- 形态 :solid
- 颜色 :white
- 敏感性 :Light Sensitive
- 危险品标志 :T
- 危险类别码 :23/24/25
- 安全说明 :22-36/37/39-45
- 危险品运输编号 :UN 1544 6.1/PG 2
- WGK Germany :3
- RTECS号 :ZG1035000
- 危险等级 :6.1
- 海关编码 :29339900
育亨宾碱性质、用途与生产工艺
- 生物活性 Rauwolscine hydrochloride是高效,选择性的 α2 adrenergic 受体拮抗剂,Ki 值为12 nM。
-
靶点
Target Value α2 adrenergic receptor
()12 nM(Ki) -
体外研究
[ 3 H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [ 3 H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes. [ 3 H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors. When using [ 3 H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (K i human=14.3 nM, K i rat=35.8 nM). Saturation studies shows that the affinity of [ 3 H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) .
- 更新日期:2024/11/08
- 产品编号:HY-12710
- 产品名称:育亨宾碱 Rauwolscine
- CAS编号:
- 包装:1 mg
- 价格:2320元
- 更新日期:2024/11/08
- 产品编号:HY-12710
- 产品名称:育亨宾碱 Rauwolscine
- CAS编号:
- 包装:5 mg
- 价格:5800元
- 公司名称:CR Chemical Resources
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- 国家:印度
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- 公司名称:Pharmaffiliates Analytics and Synthetics P. Ltd
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- 国家:印度
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- 公司名称:CLEARSYNTH LABS LTD.
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- 国家:印度
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