ChemicalBook CAS数据库列表 (3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮
- CAS号:919091-63-7
- 英文名:RA-9
- 中文名:(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮
- CBNumber:CB16188329
- 分子式:C19H15N3O5
- 分子量:365.34
- MOL File:919091-63-7.mol
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮化学性质
- 熔点 :230-233 °C(Solv: ethyl ether (60-29-7); acetonitrile (75-05-8))
- 沸点 :588.5±50.0 °C(Predicted)
- 密度 :1.414±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 4.17 mg/mL (11.41 mM; ultrasonic and warming and heat to 80°C)
- 酸度系数(pKa) :5.13±0.20(Predicted)
- 形态 :Solid
- 颜色 :Light yellow to yellow
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮性质、用途与生产工艺
- 生物活性 RA-9 是一种具有细胞渗透性的蛋白酶体相关的 deubiquitinating enzymes (DUBs) 的强效选择性抑制剂，具有良好的毒性和抗癌活性。RA-9 可在卵巢癌细胞系中选择性地诱导凋亡。
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靶点
Target Value DUBs
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体外研究
RA-9 (10-30 μM; 48 hours) inhibits growth of ovarian cancer cell lines and primary cultures.
RA-9 (1.25-5 μM; 18 hours) causes cell cycle arrest and caspase-mediated apoptosis in ovarian cancer cells.
RA-9 (5 μM; 0-24 hours) induces ER-stress responses in ovarian cancer cells.
RA-9 (5 μM; over 24 hours) treatment results with time-dependent accumulation of the cleaved formed of PARP noticeable as early as 8 hours.Cell Viability Assay
Cell Line: Cisplatin-sensitive ovarian cancer cell lines TOV-21G and ES-2, Cisplatin-resistant ovarian cancer cell lines HEY and OVCAR-3, primary ovarian cancer cells Concentration: 10, 20, 30 μM Incubation Time: 48 hours Result: Compromised the viability of ovarian cancer cells in a dose-dependent fashion. Cell Cycle Analysis
Cell Line: ES-2 cells Concentration: 1.25, 5 μM Incubation Time: 18 hours Result: Resulted in a dose-dependent increase in the fraction of ES-2 cells in the G2-M cell cycle phase. Western Blot Analysis
Cell Line: ES-2, SKOV-3 and TOV-21G ovarian cancer cells Concentration: 5 μM Incubation Time: 0-24 h Result: Caused a time-dependent increase in the steady levels of the early ER-stress marker GRP-78, as well as the late ER-stress markers IRE1-α and Ero1L-α. -
体内研究
RA-9 (5 mg/kg; i.p; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer.
Animal Model: Six-week-old female immunodeficient (NCr nu/nu) mice Dosage: 5 mg/kg Administration: I.p; one-day on, two-days off Result: Significant reduction in tumor burden at day 12.
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮上下游产品信息
上游原料
下游产品
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮 试剂级价格
- 更新日期：2024/11/08
- 产品编号：S0884
- 产品名称：(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮 RA-9
- CAS编号：919091-63-7
- 包装：5mg
- 价格：794.58元
- 更新日期：2024/11/08
- 产品编号：S0884
- 产品名称：(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮 RA-9
- CAS编号：919091-63-7
- 包装：25mg
- 价格：2432.03元
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮生产厂家
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32161
- 优势度：58
- 公司名称：InvivoChem
- 联系电话：+1-708-310-1919 +1-13798911105
- 电子邮件：sales@invivochem.cn
- 国家：美国
- 产品数：6391
- 优势度：58
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：57505
- 优势度：58
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：
- 电子邮件：support@targetmol.com
- 国家：美国
- 产品数：38631
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
