(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮
英文名称:RA-9
CAS号:919091-63-7
分子式:C19H15N3O5
分子量:365.34
EINECS号:
Mol文件:919091-63-7.mol
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮 性质
| 熔点 | 230-233 °C(Solv: ethyl ether (60-29-7); acetonitrile (75-05-8)) |
|---|---|
| 沸点 | 588.5±50.0 °C(Predicted) |
| 密度 | 1.414±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：4.17 mg/mL（11.41 mM；超声加热并加热至 80°C） |
| 酸度系数(pKa) | 5.13±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
| InChI | 1S/C19H15N3O5/c23-19-15(9-13-1-5-17(6-2-13)21(24)25)11-20-12-16(19)10-14-3-7-18(8-4-14)22(26)27/h1-10,20H,11-12H2/b15-9+,16-10+ |
| InChIKey | YUYPWAMLWZVHAE-KAVGSWPWSA-N |
| SMILES | O=C(/C(CNC/1)=C/C2=CC=C([N+]([O-])=O)C=C2)C1=C\C3=CC=C([N+]([O-])=O)C=C3 |
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮 用途与合成方法
RA-9 是一种具有细胞渗透性的蛋白酶体相关的 deubiquitinating enzymes (DUBs) 的强效选择性抑制剂，具有良好的毒性和抗癌活性。RA-9 可在卵巢癌细胞系中选择性地诱导凋亡。
| Target | Value |
|
DUBs
() |
RA-9 (10-30 μM; 48 hours) inhibits growth of ovarian cancer cell lines and primary cultures.
RA-9 (1.25-5 μM; 18 hours) causes cell cycle arrest and caspase-mediated apoptosis in ovarian cancer cells.
RA-9 (5 μM; 0-24 hours) induces ER-stress responses in ovarian cancer cells.
RA-9 (5 μM; over 24 hours) treatment results with time-dependent accumulation of the cleaved formed of PARP noticeable as early as 8 hours.
Cell Viability Assay
| Cell Line: | Cisplatin-sensitive ovarian cancer cell lines TOV-21G and ES-2, Cisplatin-resistant ovarian cancer cell lines HEY and OVCAR-3, primary ovarian cancer cells |
| Concentration: | 10, 20, 30 μM |
| Incubation Time: | 48 hours |
| Result: | Compromised the viability of ovarian cancer cells in a dose-dependent fashion. |
Cell Cycle Analysis
| Cell Line: | ES-2 cells |
| Concentration: | 1.25, 5 μM |
| Incubation Time: | 18 hours |
| Result: | Resulted in a dose-dependent increase in the fraction of ES-2 cells in the G2-M cell cycle phase. |
Western Blot Analysis
| Cell Line: | ES-2, SKOV-3 and TOV-21G ovarian cancer cells |
| Concentration: | 5 μM |
| Incubation Time: | 0-24 h |
| Result: | Caused a time-dependent increase in the steady levels of the early ER-stress marker GRP-78, as well as the late ER-stress markers IRE1-α and Ero1L-α. |
RA-9 (5 mg/kg; i.p; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer.
| Animal Model: | Six-week-old female immunodeficient (NCr nu/nu) mice |
| Dosage: | 5 mg/kg |
| Administration: | I.p; one-day on, two-days off |
| Result: | Significant reduction in tumor burden at day 12. |
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-136528 | (3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮 | 919091-63-7 | 5 mg | 175 |
| 2026-09-15 | HY-136528 | (3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮 | 919091-63-7 | 10 mg | 280 |
(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮供应商 更多
上海源叶生物科技有限公司
联系电话： 18916372613
产品介绍：
中文名称：RA-9
英文名称：(3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-4-piperidinone
CAS：919091-63-7
纯度：98%
包装信息：5mg
备注：S89411
天津凯利奇生物科技有限公司
联系电话： 15076683720
产品介绍：
英文名称：RA-9
CAS：919091-63-7
纯度：大于98%
包装信息：1g,5g,10g,25g根据客户需要分装
备注：Not For Human Use, Lab Use Only.
上海瀚香生物科技有限公司
联系电话：177-54423994 17754423994
产品介绍：
英文名称：RA-9
CAS：919091-63-7
纯度：98% HPLC LCMS
包装信息：100mg;500mg;1g
备注：现货，仅供科研用途
上海超岚化工科技中心
联系电话：QQ：65489617 13301690235
产品介绍：
英文名称：RA-9
CAS：919091-63-7
纯度：98
包装信息：1G,5G,10G,50G,100G,500G
备注：仅用于药证申报和科学研究，不为任何个人提供产品和服务
ChemeGen 中国
联系电话： 18818260767
产品介绍：
英文名称：RA-9
CAS：919091-63-7
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
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