ChemicalBook CAS数据库列表 Compound 48/80 (hydrochloride)
Compound 48/80 (hydrochloride)
- CAS号:848035-21-2
- 英文名:Compound 48/80 (hydrochloride)
- 中文名:Compound 48/80 (hydrochloride)
- CBNumber:CB14666319
- 分子式:C32H48Cl3N3O3
- 分子量:629.10082
- MOL File:848035-21-2.mol
Compound 48/80 (hydrochloride)化学性质
- 储存条件 :Store at -20°C, sealed storage, away from moisture ,protect from light
- 溶解度 :Water: 100 mM
- 形态 :A solid
- 颜色 :White to off-white
Compound 48/80 (hydrochloride)性质、用途与生产工艺
- 生物活性 Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。
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体外研究
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80.
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体内研究
Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation.Animal Model: 7-week-old Wistar male rats (fasted for 24 hours) Dosage: 0.75 mg/kg Administration: Intraperitoneal injection; Killed after 0.5, 3 or 6 h Result: Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.
Compound 48/80 (hydrochloride)上下游产品信息
上游原料
下游产品
Compound 48/80 (hydrochloride)生产厂家
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:Aladdin Scientific
- 联系电话:+1-+1(833)-552-7181
- 电子邮件:sales@aladdinsci.com
- 国家:美国
- 产品数:52927
- 优势度:58
- 公司名称:CAYMAN
- 联系电话:--
- 电子邮件:cayman@caymanchem.com
- 国家:美国
- 产品数:6618
- 优势度:81
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58