Compound 48/80 (hydrochloride)
英文名称:Compound 48/80 (hydrochloride)
CAS号:848035-21-2
分子式:C32H48Cl3N3O3
分子量:629.10082
EINECS号:
Mol文件:848035-21-2.mol
Compound 48/80 (hydrochloride) 性质
| 储存条件 | Store at -20°C, sealed storage, away from moisture ,protect from light |
|---|---|
| 溶解度 | 水：100mM |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Compound 48/80 (hydrochloride) 用途与合成方法
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80.
Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation.
| Animal Model: | 7-week-old Wistar male rats (fasted for 24 hours) |
| Dosage: | 0.75 mg/kg |
| Administration: | Intraperitoneal injection; Killed after 0.5, 3 or 6 h |
| Result: | Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter. |
Compound 48/80 (hydrochloride)供应商 更多
上海麦克林生化科技股份有限公司
联系电话：15221275939 15221275939
产品介绍：
英文名称：Compound 48/80 hydrochloride
CAS：848035-21-2
纯度：98%
包装信息：10mg
ChemeGen 中国
联系电话： 18818260767
产品介绍：
英文名称：Compound 48/80 trihydrochloride
CAS：848035-21-2
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
天津普西唐生物医药科技有限公司
联系电话：010-60605840 15801484223;
产品介绍：
英文名称：Compound 48/80 trihydrochloride
CAS：848035-21-2
纯度：98%
包装信息：50mg
上海迈瑞尔生化科技有限公司
联系电话： 18621169109
产品介绍：
英文名称：Compound 48/80 hydrochloride
CAS：848035-21-2
纯度：98%
包装信息：10mg;50mg
备注：M64205
上海一飞生物科技有限公司
联系电话：021-65675885 18964387627
产品介绍：
英文名称：Compound 48/80 (hydrochloride)
CAS：848035-21-2
纯度：95%
包装信息：100mg
备注：试剂级
