ChemicalBook CAS数据库列表 化合物 T25953
化合物 T25953
- CAS号:1177131-02-0
- 英文名:sodium (E)-4-((3-(4-nitrophenyl)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl)benzenesulfonate
- 中文名:化合物 T25953
- CBNumber:CB14107500
- 分子式:C21H16N5NaO6S
- 分子量:489.44
- MOL File:1177131-02-0.mol
化合物 T25953化学性质
- 形态 :Solid
- 颜色 :Brown to reddish brown
化合物 T25953性质、用途与生产工艺
- 生物活性 PHPS1 sodium 是一种有效的选择性 Shp2 抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 Ki 值分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
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靶点
Ki: 0.73 μM (Shp2), 5.8 μM (Shp2-R362K), 10.7 μM (Shp1), 5.8 μM (PTP1B), 0.47 μM (PTP1B-Q)
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体外研究
PHPS1 (30 μM; 6 days) inhibits proliferation of human tumor cells.
PHPS1 (5-20 μM; 5-360 minutes) inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner.
Cell Viability Assay
Cell Line: Human cancer cell lines MDA-MB-435, HCT-116 (colon carcinoma), HCT-15 (colon carcinoma), PC-3 (prostate carcinoma), HT-29 (colon carcinoma), NCI-H661 (lung carcinoma), and Caki-1 (kidney carcinoma) Concentration: 30 μM Incubation Time: 6 days Result: Resulted in a reduction in cell number of between 0% (Caki-1) to 74% (HT-29). Western Blot Analysis
Cell Line: Madin-Darby canine kidney (MDCK) cells Concentration: 5, 10, 20 μM Incubation Time: 5, 15, 60, 120, 360 minutes Result: Inhibited HGF/SF (1 unit/mL)-induced phosphorylation and thus activation of Erk1/2 over a time period of 15 min to 6 h. In contrast, transient phosphorylation of Erk1/2 after 5 min was not affected.
Exhibited no effect on HGF/SF-induced activation of PI3K/Akt or Stat3. -
体内研究
PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr -/- mice less susceptible to atherosclerosis development.
Animal Model: Ldlr -/- (005061) mice Dosage: 3 mg/kg Administration: Intraperitoneal (i.p.) injection; every day during the last week on the high-fat diet. Result: Revealed a significant decrease in atherosclerotic plaque size in the aorta compared with the other two groups.
化合物 T25953上下游产品信息
上游原料
下游产品
化合物 T25953 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-125108
- 产品名称：PHPS1 sodium
- CAS编号：
- 包装：1 mg
- 价格：460元
- 更新日期：2024/11/08
- 产品编号：HY-125108
- 产品名称：化合物 T25953 PHPS1 sodium
- CAS编号：1177131-02-0
- 包装：5mg
- 价格：1100元
化合物 T25953生产厂家
- 公司名称：MolMall Sarl
- 联系电话：--
- 电子邮件：info@molmall.net
- 国家：瑞士
- 产品数：6882
- 优势度：58
