化合物 T25953
中文名称:化合物 T25953
英文名称:sodium (E)-4-((3-(4-nitrophenyl)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl)benzenesulfonate
CAS号:1177131-02-0
分子式:C21H16N5NaO6S
分子量:489.44
EINECS号:
Mol文件:1177131-02-0.mol
化合物 T25953 用途与合成方法
PHPS1 sodium 是一种有效的选择性 Shp2 抑制剂,对 Shp2,Shp2-R362K,Shp1,PTP1B 和 PTP1B-Q 的 Ki 值分别为 0.73,5.8,10.7,5.8 和 0.47 μM。
Ki: 0.73 μM (Shp2), 5.8 μM (Shp2-R362K), 10.7 μM (Shp1), 5.8 μM (PTP1B), 0.47 μM (PTP1B-Q)
PHPS1 (30 μM; 6 days) inhibits proliferation of human tumor cells.
PHPS1 (5-20 μM; 5-360 minutes) inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner.
Cell Viability Assay
Cell Line: | Human cancer cell lines MDA-MB-435, HCT-116 (colon carcinoma), HCT-15 (colon carcinoma), PC-3 (prostate carcinoma), HT-29 (colon carcinoma), NCI-H661 (lung carcinoma), and Caki-1 (kidney carcinoma) |
Concentration: | 30 μM |
Incubation Time: | 6 days |
Result: | Resulted in a reduction in cell number of between 0% (Caki-1) to 74% (HT-29). |
Western Blot Analysis
Cell Line: | Madin-Darby canine kidney (MDCK) cells |
Concentration: | 5, 10, 20 μM |
Incubation Time: | 5, 15, 60, 120, 360 minutes |
Result: |
Inhibited HGF/SF (1 unit/mL)-induced phosphorylation and thus activation of Erk1/2 over a time period of 15 min to 6 h. In contrast, transient phosphorylation of Erk1/2 after 5 min was not affected.
Exhibited no effect on HGF/SF-induced activation of PI3K/Akt or Stat3. |
PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr -/- mice less susceptible to atherosclerosis development.
Animal Model: | Ldlr -/- (005061) mice |
Dosage: | 3 mg/kg |
Administration: | Intraperitoneal (i.p.) injection; every day during the last week on the high-fat diet. |
Result: | Revealed a significant decrease in atherosclerotic plaque size in the aorta compared with the other two groups. |
化合物 T25953 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | HY-125108 | 1 mg | 460 | ||
2024-11-08 | HY-125108 | 化合物 T25953 | 1177131-02-0 | 5mg | 1100 |
化合物 T25953供应商 更多
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:PHPS1 Sodium
CAS:1177131-02-0
纯度:98%
包装信息:5mg;10mg;25mg
备注:试剂级
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:PHPS1 sodium
CAS:1177131-02-0
纯度:98%
包装信息:5mg
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 PHPS1 Sodium
英文名称:PHPS1 Sodium
CAS:1177131-02-0
包装信息:25mg/RMB 9850;100mg/RMB 17500;50mg/RMB 12800
上海立崎生物医学研究中心
联系电话: 18014399201
产品介绍:
英文名称:PHPS1 Sodium
CAS:1177131-02-0
纯度:98%+ HPLC
包装信息:10mg,500mg,1g,2g,5g+
南通全益生物科技有限公司
联系电话:0513-66337626 18051384581
产品介绍:
英文名称:PHPS1 Sodium
CAS:1177131-02-0
纯度:98%+ HPLC
包装信息:10mg,500mg,1g,2g,5g+,10mg,more