4-羟基查耳酮
- CAS号:2657-25-2
- 英文名:4'-HYDROXYCHALCONE
- 中文名:4-羟基查耳酮
- CBNumber:CB1342383
- 分子式:C15H12O2
- 分子量:224.25
- MOL File:2657-25-2.mol
- 熔点 :174-178 °C
- 沸点 :419.6±45.0 °C(Predicted)
- 密度 :1.191±0.06 g/cm3(Predicted)
- 储存条件 :Inert atmosphere,Room Temperature
- 溶解度 :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
- 形态 :powder to crystal
- 酸度系数(pKa) :7.72±0.15(Predicted)
- 颜色 :Light orange to Yellow to Green
- BRN :2049150
- InChIKey :UAHGNXFYLAJDIN-IZZDOVSWSA-N
- LogP :3.650 (est)
- CAS 数据库 :2657-25-2(CAS DataBase Reference)
- 危险品标志 :Xi
- 危险类别码 :36/37/38
- 安全说明 :37/39-26-37
- 海关编码 :29145090
4-羟基查耳酮性质、用途与生产工艺
- 生物活性 4'-Hydroxychalcone (P-Cinnamoylphenol)，存在于草药、香料和茶叶中，是一种刺甘草查尔酮。它具有多种生物活性，能够抑制TNF-α诱导的NF-κB通路激活、并激活BMP信号通路。
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靶点
Target Value NF-κB
() -
体外研究
4'-Hydroxychalcone (20-40 μM ; 2 hours) inhibits TNFα-induced (20 ng/mL; 6 hours) NF-kB pathway activation in a dose-dependent manner.
4'-Hydroxychalcone (0.1-25 μM ; 8 hours) inhibits proteasome activity in a dose-dependent manner but has no effect on IKK activity.
4'-Hydroxychalcone inhibits TNFα-dependent degradation of IkBα and subsequently prevents p50/p65 nuclear translocation leading to 4'-Hydroxychalcone-inhibited expression of NF-kB target genes.
4'-Hydroxychalcone affects cancer cell viability but has no significant effect on non-transformed cell viability.
Cell Viability Assay
Cell Line: K562 cells, Jurkat cells, U937 cells, PBMCs Concentration: 5 μM, 10 μM, 20 μM, 24 μM, 28 μM, 32 μM, 40 μM, 60 μM Incubation Time: 24 hours Result: Affected cancer cell viability but has no significant effect on non-transformed cell viability. Western Blot Analysis
Cell Line: Jurkat cells Concentration: 60 μM (followed by TNFα 20 ng/mL ) Incubation Time: 2 hours Result: Inhibited TNFα -dependent degradation of IkBα and prevents p50/p65 nuclear translocation. -
体内研究
4'-Hydroxychalcone has hepatoprotective activity against Acetaminophen induced hepatotoxicity in mice.
Animal Model: Male albino mice(5-30 g) Dosage: 25 mg/kg, 50 mg/kg, 100 mg/kg Administration: Oral administration, 12h intervals, 4 doses Result: Significantly reduced the mortality rate induced by Acetaminophen (1 g/kg).
- 更新日期：2024/11/08
- 产品编号：A10838
- 产品名称：4'-羟基查耳酮, 97% 4'-Hydroxychalcone, 97%
- CAS编号：2657-25-2
- 包装：5g
- 价格：712元
- 更新日期：2024/11/08
- 产品编号：A10838
- 产品名称：4'-羟基查耳酮, 97% 4'-Hydroxychalcone, 97%
- CAS编号：2657-25-2
- 包装：25g
- 价格：1705元
- 公司名称：Acros Organics
- 联系电话：--
- 电子邮件：info@acros.com
- 国家：比利时
- 产品数：6772
- 优势度：81
