GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2
- CAS号:87096-84-2
- 英文名:NEUROMEDIN B
- 中文名:GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2
- CBNumber:CB1328763
- 分子式:C52H73N15O12S
- 分子量:1132.29
- MOL File:87096-84-2.mol
- 沸点 :1697.4±65.0 °C(Predicted)
- 密度 :1.337±0.06 g/cm3(Predicted)
- 储存条件 :−20°C
- 溶解度 :H2O : 12.5 mg/mL (11.04 mM; Need ultrasonic)
- 形态 :Solid
- 酸度系数(pKa) :13.16±0.46(Predicted)
- 颜色 :White to off-white
- 水溶解性 :Soluble to 1 mg/ml in water
- 序列 :H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
- WGK Germany :3
GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2性质、用途与生产工艺
- 生物活性 Neuromedin B 是一种含10个氨基酸的神经肽，属于蛙肽家族，为铃蟾肽相关肽。
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靶点
Human Endogenous Metabolite
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体外研究
Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC 50 ) is only 5% of BN (EC 50 of BN/EC 50 of NMB) and about 10% of GRP (EC 50 of GRP/ EC 50 of NMB).
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体内研究
Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED 50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively.
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参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
- 更新日期：2024/11/08
- 产品编号：HY-P0241
- 产品名称：GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 Neuromedin B
- CAS编号：87096-84-2
- 包装：1mg
- 价格：800元
- 更新日期：2024/11/08
- 产品编号：HY-P0241
- 产品名称：GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 Neuromedin B
- CAS编号：87096-84-2
- 包装：5mg
- 价格：2000元
- 公司名称：NEOMPS
- 联系电话：--
- 电子邮件：neo@neomps.com
- 国家：法国
- 产品数：2083
- 优势度：71
