1384268-04-5

1384268-04-5化学性质

沸点 :502.0±50.0 °C(Predicted)
密度 :1.263±0.06 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMF:30.0(Max Conc. mg/mL);96.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.96(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);80.03(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.2(Max Conc. mM)
形态 :A solid
酸度系数(pKa) :7.12±0.40(Predicted)
颜色 :Yellow to orange

1384268-04-5性质、用途与生产工艺

生物活性 SYP-5 是一种 Hypoxia-inducible factor-1 (HIF-1) 的抑制剂，可抑制肿瘤细胞迁移和侵袭以及肿瘤血管生成。
靶点
Target Value
HIF-1
()
体外研究

SYP-5 inhibits hypoxia-induced upregulation of HIF-1. SYP-5 inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down-regulated by SYP-5. SYP-5 displays significant inhibition on hypoxia-induced overexpression of VEGF and MMP2 in both cell lines. In the tube formation assay, SYP-5 suppresses angiogenesis induced by hypoxia and VEGF in vitro. SYP-5 also retards the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS. SYP-5 specifically inhibits hypoxic induction of luciferase expression in U251-HRE but not in U251-pGL3.

1384268-04-5上下游产品信息

上游原料

下游产品

1384268-04-5 试剂级价格

1384268-04-5生产厂家

Target	Value
HIF-1 ()