1384268-04-5
1384268-04-5 性质
| 沸点 | 502.0±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.263±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF:30.0(最大浓度 mg/mL);96.04(最大浓度 mM) DMF:PBS (pH 7.2) (1:2):0.3(最大浓度 mg/mL);0.96(最大浓度. mM) DMSO:25.0(最大浓度 mg/mL);80.03(最大浓度 mM) 乙醇:1.0(最大浓度 mg/mL);3.2(最大浓度 mM) |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.12±0.40(Predicted) |
| 颜色 | 黄至橙色 |
1384268-04-5 用途与合成方法
| Target | Value |
|
HIF-1
() |
SYP-5 inhibits hypoxia-induced upregulation of HIF-1. SYP-5 inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down-regulated by SYP-5. SYP-5 displays significant inhibition on hypoxia-induced overexpression of VEGF and MMP2 in both cell lines. In the tube formation assay, SYP-5 suppresses angiogenesis induced by hypoxia and VEGF in vitro. SYP-5 also retards the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS. SYP-5 specifically inhibits hypoxic induction of luciferase expression in U251-HRE but not in U251-pGL3.
1384268-04-5 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-100693 | 1384268-04-5 | 1384268-04-5 | 5mg | 910 |
| 2024-11-08 | HY-100693 | 1384268-04-5 | 1384268-04-5 | 10mM * 1mLin DMSO | 1001 |
