生物活性 靶点 体外研究 体内研究
ChemicalBook  CAS数据库列表  1638241-89-0

1638241-89-0

1638241-89-0,1638241-89-0,结构式
1638241-89-0
  • CAS号:1638241-89-0
  • 英文名:STING-Inducer-1
  • 中文名:1638241-89-0
  • CBNumber:CB13041465
  • 分子式:C20H24N10O10P2S2
  • 分子量:690.54
  • MOL File:1638241-89-0.mol
1638241-89-0化学性质
  • 沸点 :1020.8±75.0 °C(Predicted)
  • 密度 :2.43±0.1 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :DMSO : 2 mg/mL (2.90 mM)
  • 形态 :Solid
  • 酸度系数(pKa) :-0.67±0.70(Predicted)
  • 颜色 :White to off-white
  • InChIKey :IZJJFUQKKZFVLH-UUXHIKLWNA-N

1638241-89-0性质、用途与生产工艺

  • 生物活性 ADU-S100 (MIW815) 是干扰素基因刺激物的激活剂 (STING),具有有效的抗肿瘤和免疫活性。
  • 靶点

    STING

  • 体外研究

    ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.

  • 体内研究

    ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.

1638241-89-0上下游产品信息
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下游产品
1638241-89-0生产厂家
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