1638241-89-0
1638241-89-0 性质
| 沸点 | 1020.8±75.0 °C(Predicted) |
|---|---|
| 密度 | 2.43±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：2 mg/mL（2.90 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | -0.67±0.70(Predicted) |
| 颜色 | 白色至米白色 |
| InChIKey | IZJJFUQKKZFVLH-UUXHIKLWNA-N |
| SMILES | NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP4([S-])=O)[C@@H](COP(O[C@H]5[C@@H](O)[C@H](N(C=N6)C7=C6C(N)=NC=N7)O[C@@H]5CO4)([S-])=O)O3.[R].[R].[Na+] |
1638241-89-0 用途与合成方法
STING
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.
1638241-89-0 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-12885 | 1638241-89-0 | 1638241-89-0 | 1 mg | 3300 |
| 2026-09-15 | HY-12885 | 1638241-89-0 | 1638241-89-0 | 10 mM * 1 mL in Water | 10027 |
