利普司他丁-1

利普司他丁-1化学性质

沸点 :581.4±50.0 °C(Predicted)
密度 :1.32±0.1 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :Soluble in DMSO (15 mg/ml)
形态 :powder
酸度系数(pKa) :9.45±0.40(Predicted)
颜色 :white to light brown
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.

利普司他丁-1性质、用途与生产工艺

生物活性 Liproxstatin-1 是一种有效的 ferroptosis 抑制剂。
体外研究 Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4^−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4^−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H₂O₂ (200 µM).
体内研究 Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.
生物活性 Liproxstatin-1是一种有效的ferroptosis抑制剂，IC50为22 nM。
靶点
Target Value
ferroptosis
(Cell-free assay) 22 nM
体外研究
Liproxstatin-1能够在低纳摩尔范围内抑制铁死亡和Gpx4
体内研究与溶剂对照组相比，Liproxstatin-1可显著地延长生存期，抑制管状细胞中铁死亡，减轻缺血/再灌注诱发的肝损伤中的组织损伤。

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利普司他丁-1生产厂家

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Target	Value
ferroptosis (Cell-free assay)	22 nM