ChemicalBook CAS数据库列表 SK1-I
SK1-I
- CAS号:1072443-89-0
- 英文名:SK1-I
- 中文名:SK1-I
- CBNumber:CB12535697
- 分子式:C17H27NO2
- 分子量:277.41
- MOL File:1072443-89-0.mol
SK1-I化学性质
- 沸点 :452.9±45.0 °C(Predicted)
- 密度 :1.039±0.06 g/cm3(Predicted)
- 形态 :White solid.
- 酸度系数(pKa) :13.57±0.20(Predicted)
- 颜色 :Off-white to light yellow
SK1-I性质、用途与生产工艺
- 生物活性 SK1-I (BML-258) 是鞘氨醇的类似物,是同功酶特异性 SPHK1 竞争抑制剂,Ki 值为 10 µM。SK1-I (BML-258) 具有良好的水溶性。SK1-I (BML-258) 对 SPHK2,PKCα,PKCδ,PKA,AKT1,ERK1,EGFR,CDK2,IKKβ 或 CamK2β 无活性。SK1-I (BML-258) 增强自噬并具有抗肿瘤活性。
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靶点
Ki: 10 µM (SPHK1)
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体外研究
SK1-I (0-10 μM; 24 hours) attenuates cancer cell growth and survival in a TP53-dependent manner in HCT116 cells and HCT116 cells bearing TP53 null cancer.
SK1-I (0-20 μM; 12 hours) induces more CASP3 cleavage in HCT116 cells, compared to HCT116 cells lacking TP53, leading to a hallmark of apoptosis.Cell Viability Assay
Cell Line: HCT116 cells and HCT116 cells bearing TP53 null cancer Concentration: 0 µM, 2.5 µM, 5 µM, 7.5 µM, 10 µM Incubation Time: 24 hours Result: Decreased cancer cell growth and survival. Western Blot Analysis
Cell Line: HCT116 cells and HCT116 cells bearing TP53 null cancer Concentration: 0 µM, 5 µM, 10 µM, 20 µM Incubation Time: 12 hours Result: Induced more CASP3 cleavage in HCT116 cells, compared to HCT116 cells lacking TP53. -
体内研究
Pre-treatment with SK1-I (BML-258; intraperitoneal (i.p.) injection; once; 24 hours prior to baseline mean arterial blood pressure (MAP) measurement; 75 mg/kg) before anandamide (i.v. injection; two doses; 1 and 10 mg/kg) significantly decreases the hypotensive response.
Animal Model: Male C57BL/6 mice (24 ± 3.5 g) Dosage: 75 mg/kg Administration: Intraperitoneal (i.p.) injection; once; 24 hours prior to baseline MAP measurement Result: Significantly lowered baseline mean arterial blood pressure (MAP).
SK1-I上下游产品信息
上游原料
下游产品
SK1-I 试剂级价格
- 更新日期:2024/08/19
- 产品编号:HY-119016
- 产品名称:SK1-I
- CAS编号:
- 包装:1 mg
- 价格:1590元
- 更新日期:2024/08/19
- 产品编号:HY-119016
- 产品名称:SK1-I SK1-I
- CAS编号:1072443-89-0
- 包装:5mg
- 价格:3500元
SK1-I生产厂家
- 公司名称:EMMX Biotechnology LLC
- 联系电话:888-539-0666
- 电子邮件:info@emmx.com
- 国家:美国
- 产品数:8449
- 优势度:60
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354
- 电子邮件:support@targetmol.com
- 国家:美国
- 产品数:19973
- 优势度:58
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58