ChemicalBook CAS数据库列表 ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
![ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈,218136-59-5,结构式](https://www.chemicalbook.com/CAS/20181012/GIF/218136-59-5.gif)
- CAS号:218136-59-5
- 英文名:α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
- 中文名:ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
- CBNumber:CB12518849
- 分子式:C27H29N5
- 分子量:423.55
- MOL File:218136-59-5.mol
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈化学性质
- 储存条件 :2-8°C
- 溶解度 :DMSO: ≥10mg/mL
- 形态 :powder
- 颜色 :white to tan
安全信息
- WGK Germany :3
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈性质、用途与生产工艺
- 应用 SC-26196 是一种有效的，具有口服活性的 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中，IC50=0.2 µM)。具有抗炎活性。
- 生物活性 SC-26196 是一种有效的，具有口服活性的 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中，IC50=0.2 µM)。具有抗炎活性。
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靶点
IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)
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体外研究
SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells.
Cell Proliferation Assay
Cell Line: PBMCs and Jurkat cells Concentration: 200 nM Incubation Time: 96 hours for PBMCs; 144 hours for Jurkat cells Result: Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.
Did not alter cell proliferation significantly in Jurkat cells. -
体内研究
SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme.
Animal Model: Male mice (12- or 15-week-old) Dosage: 0, 10, 30, and 100 mg/kg per day Administration: Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day. Result: Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈上下游产品信息
上游原料
下游产品
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-107410
- 产品名称：SC-26196
- CAS编号：
- 包装：1 mg
- 价格：522元
- 更新日期：2024/11/08
- 产品编号：HY-107410
- 产品名称：ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 SC-26196
- CAS编号：218136-59-5
- 包装：5mg
- 价格：1150元
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈生产厂家
- 公司名称：Axon Medchem BV
- 联系电话：--
- 电子邮件：info@axonmedchem.com
- 国家：荷兰
- 产品数：477
- 优势度：30
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