UK 5099
- CAS号:56396-35-1
- 英文名:2-cyano-3-(1-phenylindol-3-yl)acrylate
- 中文名:UK 5099
- CBNumber:CB11396725
- 分子式:C18H12N2O2
- 分子量:288.3
- MOL File:56396-35-1.mol
- 熔点 :235-238°C
- 沸点 :448.6±45.0 °C(Predicted)
- 密度 :1.20
- 储存条件 :2-8°C
- 溶解度 :DMSO: >20mg/mL
- 酸度系数(pKa) :1.49±0.19(Predicted)
- 形态 :powder
- 颜色 :yellow to tan
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- InChIKey :BIZNHCWFGNKBBZ-JLHYYAGUSA-M
- WGK Germany :3
UK 5099性质、用途与生产工艺
- 生物活性 UK-5099 (PF-1005023) 是线粒体丙酮酸转运蛋白 (MPC) 的有效抑制剂， 抑制丙酮酸依赖性O2消耗的 IC50 值为50 nM。
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靶点
Target Value mitochondrial pyruvate carrier
()49 μM(Ki) -
体外研究
The trypanosomal pyruvate carrier is found to be rather insensitive to inhibition by alpha-cyano-4-hydroxycinnamate (K i =17 mM) but can be completely blocked by UK-5099 (K i =49 microM). UK-5099 also inhibits the monocarboxylate transporter (MCT) . UK5099 significantly inhibits the glucose-stimulated rise in oxygen consumption in a dose-dependent manner and at 150 μM reduced oxygen consumption below basal levels. UK5099 reduces ATP levels and increases ADP and AMP levels in 832/13 cells. The UK5099 treated cells show significantly higher proportion of side population fraction and express higher levels of stemness markers Oct3/4 and Nanog. UK5099 application may be an ideal model for Warburg effect studies.
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体内研究
The MPC inhibitor UK5099 increases the glucose excursion seen during an intraperitoneal glucose tolerance test in C57BLK mice.
- 更新日期：2024/11/11
- 产品编号：XW5639635102
- 产品名称：试剂UK 5099 UK 5099
- CAS编号：
- 包装：100mg
- 价格：891元
- 更新日期：2024/11/11
- 产品编号：XW5639635101
- 产品名称：试剂UK 5099 UK 5099
- CAS编号：
- 包装：25mg
- 价格：362元
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
