洋橄榄叶素
- CAS号:37318-06-2
- 英文名:elaiophylin
- 中文名:洋橄榄叶素
- CBNumber:CB11393845
- 分子式:C54H88O18
- 分子量:1025.27
- MOL File:37318-06-2.mol
- 熔点 :179-182℃
- 沸点 :1080.5±65.0 °C(Predicted)
- 密度 :1.25
- 储存条件 :-20°C Freezer
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 酸度系数(pKa) :12.18±0.70(Predicted)
- 形态 :White to off-white solid.
- 颜色 :White to Off-White
洋橄榄叶素性质、用途与生产工艺
- 概述 盐霉素(Salinomycin)是由白色链霉菌经发酵产生的聚醚类动物专用抗生素，具有防治动物球虫病和促进畜禽生长发育的功能，被广泛地用于国内外的畜牧业中。但是，在盐霉素产品中，如果发酵工艺或菌种发生变化，将会有洋橄榄叶素的伴生，当含量超出一定限度，将对饲养对象产生不良反应，一定程度上会影响盐霉素的使用效果。
- 用途 洋橄榄叶素是一种微生物代谢物，可用作对照品。
- 生物活性 Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E) 是一种自噬 (autophagy) 抑制剂，在卵巢癌细胞中作为单一药剂发挥抗肿瘤活性。
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靶点
Autophagy
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体外研究
Elaiophylin-mediated autophagy inhibition and lysosomal dysfunction affect ovarian cancer cell survival during hypoxia. Exposure to Elaiophylin (0.025-0.5 μM; 24 hours) causes a significant increase in ovarian cancer SKOV3 cell death in hypoxia conditions.
In both the SKOV3 and A2780 cell lines, Elaiophylin (0.25, 0.5, 0.75 μM; 24 hours) treatment leads to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner.Cell Viability Assay
Cell Line: Ovarian cancer SKOV3 cells. Concentration: 0.025, 0.05, 0.1, 0.2, 0.5 μM Incubation Time: 24 hours Result: Caused a significant increase in ovarian cancer SKOV3 cells death in hypoxia conditions. Western Blot Analysis
Cell Line: Ovarian cancer SKOV3 cells; A2780 cells Concentration: 0.25, 0.5, 0.75 μM Incubation Time: 24 hours Result: Treatment led to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner. -
体内研究
Treatment with 2 mg/kg Elaiophylin (given i.p. every 2 days for 21 days; in BALB/C athymic mice) significantly suppresses ovarian cancer SKOV3 cells growth compared with DMSO treatment, resulting in a 72% decrease in the average daily tumor growth rate compared with DMSO treatment .
Lower doses of Elaiophylin as a single agent exert significant antitumor activity, while higher doses lead to intestinal toxicity. Administration of a lower dose (2 mg/kg) of Elaiophylin as a single agent achieves a significant antitumor effect without toxicity in an orthotopic ovarian cancer model with metastasis. Toxic reactions are observed only in the 8 mg/kg group.Animal Model: 4-wk-old BALB/C athymic mice with ovarian cancer SKOV3 cells Dosage: 1 or 2 mg/kg Administration: Given i.p. every 2 days for 21 days Result: Treatment with 2 mg/kg significantly suppressed ovarian cancer SKOV3 cells growth compared with DMSO treatment.
- 更新日期：2024/11/08
- 产品编号：HY-15184
- 产品名称：洋橄榄叶素 Elaiophylin
- CAS编号：37318-06-2
- 包装：1mg
- 价格：3920元
- 更新日期：2024/08/19
- 产品编号：HY-15184
- 产品名称：洋橄榄叶素 Elaiophylin
- CAS编号：37318-06-2
- 包装：5mg
- 价格：9760元
- 公司名称：Novachemistry
- 联系电话：44-20819178-90 02081917890
- 电子邮件：info@novachemistry.com
- 国家：英国
- 产品数：4381
- 优势度：58
