印楝素B
- CAS号:106500-25-8
- 英文名:AZADIRACHTIN B(SH)
- 中文名:印楝素B
- CBNumber:CB11266222
- 分子式:C33H42O14
- 分子量:662.68
- MOL File:106500-25-8.mol
- 沸点 :780.5±60.0 °C(Predicted)
- 密度 :1.49±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Chloroform: slightly soluble; DMSO: slightly soluble; Methanol: slightly soluble
- 形态 :A solid
- 酸度系数(pKa) :11.99±0.60(Predicted)
- 颜色 :White to off-white
- 稳定性 :Light Sensitive
印楝素B性质、用途与生产工艺
- 生物活性 Azadirachtin B 是从 Azadirachta indica 种子仁中分离的柠檬苦素。Azadirachtin B 增加碱性磷酸酶 (ALP) 活性并刺激成骨细胞分化。Azadirachtin B 对爱泼斯坦-巴尔病毒早期抗原 (EBV-EA) 具有活性。Azadirachtin B 具有杀虫，杀线虫，抗癌，抗炎，抗病毒和成骨特性。
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靶点
Plutella xylostella
Alkaline phosphatase (ALP)
Epstein-Barr virus early antigen (EBV-EA) -
体外研究
Azadirachtin B (1 pM-100 µM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.
Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control.
Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth ( Plutella xylostella ) with an LD 50 of 4.85-1.06 µg/g body weight, in 92 h.
Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA).Cell Proliferation Assay
Cell Line: Osteoblast cells Concentration: 1 pM, 100 pM, 10 nM, 1 µM, 100 µM Incubation Time: 48 hours Result: Showed highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells. -
体内研究
On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity.
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- 国家：印度
- 产品数：6257
- 优势度：58
