印楝素B
印楝素B 性质
| 沸点 | 780.5±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.49±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 氯仿：微溶； DMSO：微溶；甲醇：微溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.99±0.60(Predicted) |
| 颜色 | 白色至米白色 |
| 稳定性 | 感光 |
印楝素B 用途与合成方法
Plutella xylostella
Alkaline phosphatase (ALP)
Epstein-Barr virus early antigen (EBV-EA)
Azadirachtin B (1 pM-100 µM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.
Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control.
Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth (
Plutella xylostella
) with an LD
50
of 4.85-1.06 µg/g body weight, in 92 h.
Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA).
Cell Proliferation Assay
| Cell Line: | Osteoblast cells |
| Concentration: | 1 pM, 100 pM, 10 nM, 1 µM, 100 µM |
| Incubation Time: | 48 hours |
| Result: | Showed highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells. |
On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity.
印楝素B 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-133108 | 印楝素B | 106500-25-8 | 1 mg | 1500 |
| 2026-09-15 | HY-133108 | 印楝素B | 106500-25-8 | 5 mg | 3745 |
