厄他培南钠

生物活性体外研究体内研究厄他培南钠试剂级价格

厄他培南钠

CAS号:153773-82-1
英文名:Ertapenem sodium
中文名:厄他培南钠
CBNumber:CB11238838
分子式:C22H26N3NaO7S
分子量:499.51
MOL File:153773-82-1.mol

厄他培南钠化学性质

熔点 :>174oC (dec.)
储存条件 :-70°C
溶解度 :DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
形态 :powder
颜色 :white to beige
水溶解性 :Fully miscible in water. Soluble in DMSO.
稳定性 :Hygroscopic, Temperature Sensitive

厄他培南钠性质、用途与生产工艺

生物活性 Ertapenem sodium (L-749345; MK-826) 属于长效的碳青霉烯，是一种 β-内酰胺抗生素，具有广泛的抗菌谱。Ertapenem sodium 对革兰氏阳性菌和革兰氏阴性菌均有活性，包括肠杆菌科、肺炎链球菌和大多数种类的厌氧菌。
体外研究

Ertapenem sodium inhibits Streptococcus pneumoniae with MIC ₅₀ s values < 1mg/L.
Ertapenem sodium exhibits a bactericidal mode of action as shown by time-killing curves and exhibits a short postantibiotic effect (PAE) of 1.4-2.6 h against the Gram-positive strains but no PAE against Gram-negative strains.

体内研究

Ertapenem sodium (50 mg/kg; s.c.; q6h; for 24 hours) shows substantial bactericidal activity against S. pneumoniae in the murine thigh infection model.
Ertapenem sodium exhibits an AUC _0-24 of 586 mg•h/L, C _max of 140 mg/L following subcutaneous injection (mice 50 mg/kg).

Animal Model:	Specific-pathogen-free female ICR mice (~25 g), thigh infection model
Dosage:	50 mg/kg
Administration:	Subcutaneous injection, q6h, for 24 hours
Result:	Showed substantial bactericidal activities.

Animal Model:	Specific-pathogen-free female ICR mice (~25 g), thigh infection model
Dosage:	20 mg/kg, 50 mg/kg, 100 mg/kg (Pharmacokinetic Analysis)
Administration:	Subcutaneous injection
Result:	AUC _0-24 (586 mg•h/L), C _max (140 mg/L) at 50 mg/kg q6h dosing regimen.