6-氰基-7-硝基喹喔啉-2,3-二酮
- CAS号:115066-14-3
- 英文名:CNQX
- 中文名:6-氰基-7-硝基喹喔啉-2,3-二酮
- CBNumber:CB0728641
- 分子式:C9H4N4O4
- 分子量:232.15
- MOL File:115066-14-3.mol
- 熔点 :300 °C
- 沸点 :374.31°C (rough estimate)
- 密度 :1.5507 (rough estimate)
- 折射率 :1.6590 (estimate)
- RTECS号 :VD1520000
- 储存条件 :protect from light
- 溶解度 :H2O: 10 mg/mL
- 形态 :solid
- 酸度系数(pKa) :8.16±0.20(Predicted)
- 颜色 :orange to red
- 稳定性 :Store Tightly Sealed at RT
- CAS 数据库 :115066-14-3(CAS DataBase Reference)
6-氰基-7-硝基喹喔啉-2,3-二酮性质、用途与生产工艺
- 生物活性 CNQX (FG9065) 是一种有效的竞争性 AMPA /海藻酸酯受体 (AMPA/kainate receptor) 拮抗剂，IC50 分别为 0.3 μM 和 1.5 μM。CNQX 是一种竞争性的非 NMDA 受体拮抗剂。CNQX 会阻止大鼠恐惧增强的表达。
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靶点
IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)
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体外研究
CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
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体内研究
CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
Animal Model: Male Wistar rats weighing 180-200 g Dosage: 0.75, 1.5, and 3 mg/kg Administration: IP; 20 min before testing Result: Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval
- 更新日期：2024/11/08
- 产品编号：HY-15066A
- 产品名称：CNQX disodium
- CAS编号：
- 包装：5 mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-15066A
- 产品名称：CNQX disodium
- CAS编号：
- 包装：10 mg
- 价格：700元
- 公司名称：KANTO
- 联系电话：--
- 电子邮件：reag-info@gms.kanto.co.jp
- 国家：日本
- 产品数：6756
- 优势度：74
- 公司名称：NACALAI
- 联系电话：--
- 电子邮件：info-tech@nacalai.co.jp
- 国家：日本
- 产品数：6046
- 优势度：75
