6-氰基-7-硝基喹喔啉-2,3-二酮
6-氰基-7-硝基喹喔啉-2,3-二酮
6-氰基-7-硝基喹喔啉-2,3-二酮 性质
| 熔点 | 300 °C |
|---|---|
| 沸点 | 374.31°C (rough estimate) |
| 密度 | 1.5507 (rough estimate) |
| 折射率 | 1.6590 (estimate) |
| RTECS号 | VD1520000 |
| 储存条件 | protect from light |
| 溶解度 | 在水中的溶解度10 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.16±0.20(Predicted) |
| 颜色 | 橙色至红色 |
| 水溶解性 | H2O: >2mg/mL (warmed) |
| 稳定性 | 在室温下密封存放 |
| InChI | 1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15) |
| InChIKey | RPXVIAFEQBNEAX-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N |
| CAS 数据库 | 115066-14-3(CAS DataBase Reference) |
6-氰基-7-硝基喹喔啉-2,3-二酮 用途与合成方法
IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)
CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
| Animal Model: | Male Wistar rats weighing 180-200 g |
| Dosage: | 0.75, 1.5, and 3 mg/kg |
| Administration: | IP; 20 min before testing |
| Result: | Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval |
6-氰基-7-硝基喹喔啉-2,3-二酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-15066R | 6-氰基-7-硝基喹喔啉-2,3-二酮 | 115066-14-3 | 5 mg | 1100 |
| 2026-09-15 | HY-15066R | 6-氰基-7-硝基喹喔啉-2,3-二酮 | 115066-14-3 | 10 mg | 1750 |
