2',5'-DIDEOXYADENOSINE
- CAS号:6698-26-6
- 英文名:2',5'-DIDEOXYADENOSINE
- 中文名:2',5'-DIDEOXYADENOSINE
- CBNumber:CB0688918
- 分子式:C10H13N5O2
- 分子量:235.24
- MOL File:6698-26-6.mol
- 沸点 :547.0±60.0 °C(Predicted)
- 密度 :1.77±0.1 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :DMSO: soluble
- 形态 :solid
- 酸度系数(pKa) :14.06±0.60(Predicted)
- 颜色 :white
- WGK Germany :3
- 海关编码 :29349990
2',5'-DIDEOXYADENOSINE性质、用途与生产工艺
- 生物活性 2',5'-Dideoxyadenosine 是一种有效且非竞争性的腺苷酸环化酶 (adenylyl cyclase) 抑制剂，可以有效结合 P 位点，IC50 为 3 µM。2',5'-Dideoxyadenosine 是核苷类似物，在心脏中发挥强大的抗肾上腺素 (antiadrenergic) 作用。
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靶点
IC50: 3 µM (adenylyl cyclase)
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体外研究
2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448.
2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively.
Western Blot Analysis
Cell Line: Primary hippocampal neurons Concentration: 10 μM Incubation Time: 30 min Result: Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). -
体内研究
2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K + and Cl - sparing effect of Fr•EtOAc in rats.
Animal Model: Male Wistar rats (3-4 months old) Dosage: 0.1 mg/kg Administration: IP; 15 min pre-treated Result: Fully inhibited the diuretic, natriuretic and K + and Cl - sparing effect of Fr•EtOAc in rats.
- 更新日期：2024/11/08
- 产品编号：HY-135878
- 产品名称：2',5'-Dideoxyadenosine
- CAS编号：
- 包装：1 mg
- 价格：431元
- 更新日期：2024/11/08
- 产品编号：HY-135878
- 产品名称：2',5'-DIDEOXYADENOSINE 2',5'-Dideoxyadenosine
- CAS编号：6698-26-6
- 包装：5mg
- 价格：950元
- 公司名称：CHIMMED
- 联系电话：--
- 电子邮件：synthesis@chimmed.ru
- 国家：俄罗斯
- 产品数：5006
- 优势度：81
