ChemicalBook CAS数据库列表 THPP-1
THPP-1
- CAS号:1257051-63-0
- 英文名:THPP-1
- 中文名:THPP-1
- CBNumber:CB06127943
- 分子式:C23H21ClN6O3
- 分子量:464.9
- MOL File:1257051-63-0.mol
THPP-1化学性质
- 密度 :1.45±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 31.25 mg/mL (67.22 mM)
- 形态 :A solid
- 酸度系数(pKa) :4.70±0.30(Predicted)
- 颜色 :Off-white to light yellow
THPP-1性质、用途与生产工艺
- 生物活性 THPP-1 是SGC推荐的一个化学探针, 是有效的、具有口服活性的磷酸二酯酶10A (PDE10A) 的抑制剂,其对人和大鼠的 Ki 值分别为 1 nM 和 1.3 nM。THPP-1 具有良好的药理学特性。
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靶点
IC50: 1-1.3 nM (PDE10A).
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体内研究
THPP-1 (0.1-1.0 mg/kg, p.o.) shows novel object recognition in rats.
THPP-1 (p.o., 1-30 mg/kg) dose-dependently increases phosphorylation of GluR1 S845 in the rat striatum whereas the total levels of GluR1 in the striatum are not affected. Administration of THPP-1 also results in an associated increase in the pGluR1/GluR1 ratios at all doses examined in this study.
THPP-1 (1, 3, 10 mg/kg, p.o.) significantly attenuated the stimulant effects in stimulant-induced motor activity (SIMA) in monkey.Animal Model: Male Wistar Hannover rats ranging from 200 to 300 g. Dosage: 0.1-1.0 mg/kg. Administration: P.O. Result: Showed novel object recognition. Animal Model: Eleven monkeyswere surgically implanted with subcutaneous telemetric devices to permit the simultaneous recording of electrocorticogram (ECoG), electrooculogram (EOG), and electromyogram (EMG) activit Dosage: 1, 3, 10 mg/kg. Administration: P.O. Result: Significantly attenuated the stimulant effects in SIMA. Animal Model: Male Wistar Hannover rats ranging from 200 to 300 g. Dosage: 1-30 mg/kg. Administration: P.O. (10% Tween 80/90% water) 2 h prior to tissue collection ( Pharmacokinetic Analysis ). Result: Dose-dependently increases phosphorylation of GluR1 S845.
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THPP-1 试剂级价格
- 更新日期:2024/04/30
- 产品编号:HY-117604
- 产品名称:THPP-1 THPP-1
- CAS编号:1257051-63-0
- 包装:5mg
- 价格:900元
- 更新日期:2024/04/30
- 产品编号:HY-117604
- 产品名称:THPP-1 THPP-1
- CAS编号:1257051-63-0
- 包装:10mM * 1mLin DMSO
- 价格:921元
THPP-1生产厂家
- 公司名称:InvivoChem
- 联系电话:+1-708-310-1919 +1-13798911105
- 电子邮件:sales@invivochem.cn
- 国家:美国
- 产品数:6393
- 优势度:58
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354
- 电子邮件:support@targetmol.com
- 国家:美国
- 产品数:19973
- 优势度:58
- 公司名称:CAYMAN
- 联系电话:--
- 电子邮件:cayman@caymanchem.com
- 国家:美国
- 产品数:6618
- 优势度:81
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58