腺苷5'-三磷酸二钠盐水合物
- CAS号:34369-07-8
- 英文名:ADENOSINE 5'-TRIPHOSPHATE DISODIUM SAL&
- 中文名:腺苷5'-三磷酸二钠盐水合物
- CBNumber:CB0500025
- 分子式:C10H19N5NaO14P3
- 分子量:549.19
- MOL File:34369-07-8.mol
- 熔点 :176 °C (dec.)(lit.)
- 储存条件 :-20°C
- 溶解度 :H2O: soluble50mg/mL, clear, colorless
- 形态 :Powder
- 颜色 :White
- 水溶解性 :Soluble in water.
- 敏感性 :Light Sensitive & Hygroscopic
- Merck :14,155
- BRN :3585462
- 稳定性 :Hygroscopic, Temperature Sensitive
- InChIKey :NTBQNWBHIXNPRU-MSQVLRTGSA-L
- CAS 数据库 :34369-07-8
腺苷5'-三磷酸二钠盐水合物性质、用途与生产工艺
- 生物活性 ATP disodium salt hydrate (Adenosine 5'-triphosphate disodium salt hydrate) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。ATP disodium salt hydrate 是免疫和炎症中重要的内源性信号分子。
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体外研究
ATP disodium salt hydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.
ATP disodium salt hydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.
ATP disodium salt hydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis.
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体内研究
ATP disodium salt hydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.
ATP disodium salt hydrate induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo.
Animal Model: Four-week-old Kunming mice (18-22 g) Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial ( E. coli ) challenge Result: Protected mice from bacterial infection. - 用途 P2 嘌呤能激动剂；增加Ca2+-激活的K+ 通道活性；依赖ATP的酶底物。
- 更新日期：2024/11/08
- 产品编号：J10585
- 产品名称：腺苷-5′-三磷酸二钠盐，（无钙） Adenosine-5'-triphosphate disodium salt hydrate, Thermo Scientific
- CAS编号：34369-07-8
- 包装：5g
- 价格：786元
- 更新日期：2024/11/08
- 产品编号：L14522
- 产品名称：腺苷-5'-三磷酸二钠盐水合物, 99%, water <10% Adenosine-5'-triphosphate disodium salt hydrate, 99%, water <10%
- CAS编号：34369-07-8
- 包装：1g
- 价格：480元
- 公司名称：Pol-Aura
- 联系电话：--
- 电子邮件：biuro@pol-aura.pl
- 国家：波兰
- 产品数：1453
- 优势度：58
