ChemicalBook CAS数据库列表 IITZ-01
IITZ-01
- CAS号:1807988-47-1
- 英文名:IITZ-01
- 中文名:IITZ-01
- CBNumber:CB04668033
- 分子式:C26H23FN8O
- 分子量:482.51
- MOL File:1807988-47-1.mol
IITZ-01化学性质
- 沸点 :747.0±70.0 °C(Predicted)
- 密度 :1.420±0.06 g/cm3(Predicted)
- 储存条件 :under inert gas (nitrogen or Argon) at 2–8 °C
- 溶解度 :DMSO:100.0(Max Conc. mg/mL);207.24(Max Conc. mM)
- 酸度系数(pKa) :11.55±0.10(Predicted)
- 形态 :Solid
- 颜色 :White to off-white
IITZ-01性质、用途与生产工艺
- 生物活性 IITZ-01 是一个具有抗肿瘤活性的、有效的亲溶酶体的自噬抑制剂，其对 PI3Kγ 的 IC50 值为 2.62 μM。
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靶点
PI3Kγ
2.62 μM (IC 50 )
Autophagy
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体外研究
IITZ-01 (0-2 μM, 24 h) enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.
Western Blot Analysis
Cell Line: Triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). Concentration: 0-2 μM. Incubation Time: 24 hours. Result: Enhanced autophagosomes formation as indicated by increased expression of LC3-II levels. -
体内研究
IITZ-01 (45 mg/kg, i.p. every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.
Animal Model: MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr-Foxn nu BALB/c female nude mice. Dosage: 45 mg/kg. Administration: Intraperitoneal every alternate day for 4 weeks. Result: Inhibited average breast tumor growth when compared with control from third day of treatment.
IITZ-01上下游产品信息
上游原料
下游产品
IITZ-01 试剂级价格
- 更新日期：2025/02/08
- 产品编号：HY-112897
- 产品名称：IITZ-01 IITZ-01
- CAS编号：1807988-47-1
- 包装：5mg
- 价格：700元
- 更新日期：2025/02/08
- 产品编号：HY-112897
- 产品名称：IITZ-01 IITZ-01
- CAS编号：1807988-47-1
- 包装：10mM * 1mLin DMSO
- 价格：740元
IITZ-01生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
