LDN-192960 HYDROCHLORIDE
- CAS号:2309172-48-1
- 英文名:LDN-192960 (hydrochloride)
- 中文名:LDN-192960 HYDROCHLORIDE
- CBNumber:CB04666529
- 分子式:C18H21ClN2O2S
- 分子量:364.89
- MOL File:2309172-48-1.mol
- 储存条件 :Store at -20°C
- 溶解度 :DMSO:20.07(Max Conc. mg/mL);50.01(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);24.92(Max Conc. mM) - 形态 :A crystalline solid
- 颜色 :Light yellow to yellow
LDN-192960 HYDROCHLORIDE性质、用途与生产工艺
- 生物活性 LDN-192960 hydrochloride 是 Haspin 和 DYRK2 的双重抑制剂,IC50 值分别为 10 nM 和 48 nM。
-
靶点
IC50: 10 nM (Haspin); 48 nM (DYRK2)
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体外研究
LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC 50 <1 μM), including CLK1 (IC 50 =0.21 μM), DYRK1A (IC 50 = 0.10 μM), DYRK2 (IC 50 =2 nM), DYRK3 (IC 50 =19 nM) and PIM1 (IC 50 =0.72 μM).LDN-0192960 hydrochloride (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC 50 of 1.17 μM.LDN-0192960 hydrochloride (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC 50 of 0.02 μM.
- 更新日期:2024/04/30
- 产品编号:HY-13455A
- 产品名称:LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride
- CAS编号:2309172-48-1
- 包装:5mg
- 价格:2900元
- 更新日期:2024/04/30
- 产品编号:HY-13455A
- 产品名称:LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride
- CAS编号:2309172-48-1
- 包装:10mg
- 价格:4700元
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