LDN-192960 HYDROCHLORIDE
LDN-192960 HYDROCHLORIDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO:20.07(最大浓度 mg/mL);50.01(最大浓度 mM) PBS (pH 7.2):10.0(最大浓度 mg/mL);24.92(最大浓度 mM) |
| 形态 | 结晶固体 |
| 颜色 | 浅黄至黄色 |
LDN-192960 HYDROCHLORIDE 用途与合成方法
IC50: 10 nM (Haspin); 48 nM (DYRK2)
LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC 50 <1 μM), including CLK1 (IC 50 =0.21 μM), DYRK1A (IC 50 = 0.10 μM), DYRK2 (IC 50 =2 nM), DYRK3 (IC 50 =19 nM) and PIM1 (IC 50 =0.72 μM).LDN-0192960 hydrochloride (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC 50 of 1.17 μM.LDN-0192960 hydrochloride (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC 50 of 0.02 μM.
LDN-192960 HYDROCHLORIDE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-13455A | LDN-192960 HYDROCHLORIDE | 2309172-48-1 | 5mg | 2900 |
| 2024-04-30 | HY-13455A | LDN-192960 HYDROCHLORIDE | 2309172-48-1 | 10mg | 4700 |
