ChemicalBook CAS数据库列表 1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
- CAS号:1610022-76-8
- 英文名:1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
- 中文名:1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
- CBNumber:CB03353619
- 分子式:C21H22ClN3O2
- 分子量:383.87
- MOL File:1610022-76-8.mol
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide化学性质
- 密度 :1.23±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 260 mg/mL (677.31 mM)
- 形态 :Solid
- 酸度系数(pKa) :8.44±0.50(Predicted)
- 颜色 :White to off-white
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide性质、用途与生产工艺
- 生物活性 Nrf2-IN-1 是 Nrf2 的抑制剂,被用于急性髓性白血病 (AML) 药物研究。
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靶点
Nrf2
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体外研究
Nrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation.
Nrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell.
Nrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro.
Nrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax.
Cell Viability Assay
Cell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 1 μM, 5 μM, 10 μM, 20 μM Incubation Time: 48 hours Result: Inhibited growth of the three AML cell types at 5 μM, 10 μM or 20 μM for 48 hours. Apoptosis Analysis
Cell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Induced apoptosis in AML cells in vitro. Western Blot Analysis
Cell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Triggered caspase-dependent apoptotic signaling in AML cells. -
体内研究
Nrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs.
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide上下游产品信息
上游原料
下游产品
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide生产厂家
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:Aladdin Scientific
- 联系电话:+1-+1(833)-552-7181
- 电子邮件:sales@aladdinsci.com
- 国家:美国
- 产品数:52927
- 优势度:58
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58