ChemicalBook CAS数据库列表 METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-
METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-
- CAS号:152831-00-0
- 英文名:(3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxybenzofuran-3-yl)methanone
- 中文名:METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-
- CBNumber:CB03340079
- 分子式:C17H12Br2O4
- 分子量:440.08
- MOL File:152831-00-0.mol
METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-化学性质
- 沸点 :444.9±45.0 °C(Predicted)
- 密度 :1.785±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 酸度系数(pKa) :4.53±0.25(Predicted)
- 形态 :Solid
- 颜色 :Off-white to light yellow
METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-性质、用途与生产工艺
- 生物活性 6-Hydroxybenzbromarone 是 Benzbromarone 的主要代谢产物 (metabolite)，比母体化合物具有更长的半衰期和更大的药理效力。6-Hydroxybenzbromarone 是一种 EYA3 抑制剂，IC50 值为 21.5 μM。6-Hydroxybenzbromarone 是一种血管生成剂，对细胞迁移，肾小管生成和血管生成具有强大的抑制作用。
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靶点
IC50: 21.5 μM (EYA3); metabolite
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体外研究
6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding.
Cell Proliferation Assay
Cell Line: HUVEC cells Concentration: 7.5 μM Incubation Time: 72 hours Result: Inhibited HUVEC cells proliferation.
METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-上下游产品信息
上游原料
下游产品
METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
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