左旋沙丁胺醇

生物活性体外研究体内研究

左旋沙丁胺醇

CAS号:34391-04-3
英文名:Salbutamol
中文名:左旋沙丁胺醇
CBNumber:CB0275903
分子式:C13H21NO3
分子量:239.31
MOL File:34391-04-3.mol

左旋沙丁胺醇化学性质

沸点 :433.5±40.0 °C(Predicted)
密度 :1.152±0.06 g/cm3(Predicted)
酸度系数(pKa) :9.99±0.31(Predicted)
InChI :InChI=1/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3/t12-/s3
InChIKey :NDAUXUAQIAJITI-PLAQIDKDNA-N
SMILES :C1(=CC=C(O)C(CO)=C1)[C@@H](O)CNC(C)(C)C |&1:9,r|
CAS 数据库 :34391-04-3(CAS DataBase Reference)

安全信息

危险品标志 :Xn
危险类别码 :22
安全说明 :36

左旋沙丁胺醇性质、用途与生产工艺

生物活性 Levalbuterol ((R)-Albuterol; (R)-Salbutamol) 是短效 β2-肾上腺素受体 (β2-adrenergic receptor) 激动剂和 Salbutamol 的活性 R 型对映异构体。Levalbuterol 是一种比 Salbutamol 更有效的支气管扩张试剂，可用于哮喘和慢性阻塞性肺疾病 (COPD) 的研究。

体外研究

Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2 expression in airway epithelial cells.Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line.

RT-PCR

Cell Line:	Murine Club (MTCC) cells
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Increased 11β-HSD1 mRNA expression selectively.

体内研究

Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE.

Animal Model:	C57BL/6 female mice with a pulmonary allergic model
Dosage:	1 mg/kg
Administration:	Subcutaneous injection; 1 mg/kg; 14 days
Result:	Decreased pulmonary inflammation after OVA sensitization.