替拉鲁替尼

替拉鲁替尼试剂级价格

替拉鲁替尼化学性质

沸点 :672.0±65.0 °C(Predicted)
密度 :1.412±0.06 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMSO:65.0(Max Conc. mg/mL);143.02(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.66(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);66.01(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.2(Max Conc. mM)
形态 :A crystalline solid
酸度系数(pKa) :3.16±0.20(Predicted)
颜色 :White to yellow

替拉鲁替尼性质、用途与生产工艺

用途一种有效的口服活性的BTK(布鲁顿酪氨酸激酶)抑制剂, IC50:2.2nM。Tirabrutinib is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. As a result, this agent may inhibit the proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

替拉鲁替尼上下游产品信息

上游原料

下游产品

替拉鲁替尼试剂级价格

替拉鲁替尼生产厂家

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