2'-脱氧胞苷-5'-三磷酸三钠盐

2'-脱氧胞苷-5'-三磷酸三钠盐化学性质

储存条件 :-20°C
溶解度 :Water: 10 mg/ml
形态 :A crystalline solid
颜色 :Colorless to light yellow
水溶解性 :Water: 10 mg/ml
InChIKey :WBIPTAOOMJEGQO-JXXKLNQHNA-K
SMILES :N1(C=CC(N)=NC1=O)[C@H]1C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)O)O1.[Na+].[Na+].[Na+] |&1:8,10,12,r|
CAS 数据库 :109909-44-6(CAS DataBase Reference)

2'-脱氧胞苷-5'-三磷酸三钠盐性质、用途与生产工艺

生物活性 Deoxycytidine triphosphate trisodium salt (dCTP trisodium salt) 是可用于 DNA 合成 (DNA synthesis) 的核苷三磷酸。Deoxycytidine triphosphate trisodium salt 可用于实时 PCR，cDNA 合成和 DNA 测序等研究。
体外研究

Assays of thirteen cell lines, derived from mouse lymphomas, myelomas, myeloid tumors, and a mastocytoma, for sensitivity to growth inhibition by 1-β-D-arabinofuranosylcytosine (ara-C) revealed a spectrum between the most and least sensitive which differed 100-fold from each other. An inverse correlation between sensitivity and cellular Deoxycytidine triphosphate (2′-Deoxycytidine-5′-triphosphate, dCTP) content is found, and this suggested that sensitivity of cells might be increased if the dCTP content was lowered during cell exposure to ara-C.
Deoxycytidine triphosphate trisodium salt is a phosphoethanolamine cytidylyltransferase substrate.

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