PF 3845
- CAS号:1196109-52-0
- 英文名:PF 3845
- 中文名:PF 3845
- CBNumber:CB02518802
- 分子式:C24H23F3N4O2
- 分子量:456.46
- MOL File:1196109-52-0.mol
- 沸点 :623.6±55.0 °C(Predicted)
- 密度 :1.323±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: ≥45mg/mL
- 酸度系数(pKa) :14.14±0.40(Predicted)
- 形态 :powder
- 颜色 :white to tan
PF 3845性质、用途与生产工艺
- 生物活性 PF-3845 是一种有效的，选择性的，不可逆和具有口服活性的脂肪酸酰胺水解酶 (FAAH) 抑制剂，Ki 值为 0.23 µM。PF-3845 是将 FAAH 的丝氨酸亲核试剂氨基甲酸酯化的共价抑制剂。PF-3845 可以减少疼痛感，炎症和焦虑/抑郁，而对运动或认知没有实质性影响。
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靶点
Ki: 0.23 µM (FAAH)
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体外研究
PF-3845 (0.5 nM-10 μM; 40 min) inhibits human FAAH-1 (IC 50 =18 nM) in a concentration-dependent manner, and shows negligible activity against FAAH-2 (IC 50 >10 μM) in COS-7 cells.
PF-3845 (0.1-1000 μM; 48 h) significantly decreases the Colo-205 cell viability. -
体内研究
PF-3845 (1-30 mg/kg; p.o.) produces cannabinoid receptor-dependent reductions in inflammatory pain in rat.
PF-3845 (10 mg/kg; a single i.p.) selectively inhibits FAAH in mice for up to 24 hours.
PF-3845 (10 mg/kg; a single i.p.) causes a dramatic and sustained elevation in Anandamide (AEA) in mice.Animal Model: Male Sprague-Dawley rats (200g- 250g) are injected CFA Dosage: 1, 3, 10, 30 mg/kg Administration: Oral administration Result: Caused a dose-dependent inhibition of mechanical allodynia with a minimum effective dose (MED) of 3 mg/kg. -
用途
PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. D isplays no activity at FAAH-2 (IC50 >10 μM).
- 更新日期：2024/11/08
- 产品编号：HY-14380
- 产品名称：PF-3845
- CAS编号：
- 包装：1 mg
- 价格：278元
- 更新日期：2024/11/08
- 产品编号：HY-14380
- 产品名称：PF 3845 PF-3845
- CAS编号：1196109-52-0
- 包装：5mg
- 价格：512元
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
