N-ETHYLLIDOCAINE BROMIDE
- CAS号:24003-58-5
- 英文名:N-ETHYLLIDOCAINE BROMIDE
- 中文名:N-ETHYLLIDOCAINE BROMIDE
- CBNumber:CB02463601
- 分子式:C16H27BrN2O
- 分子量:343.31
- MOL File:24003-58-5.mol
- 熔点 :214-215 °C
- 储存条件 :Desiccate at RT
- 溶解度 :insoluble in EtOH; ≥10.5 mg/mL in H2O; ≥25.55 mg/mL in DMSO
- 形态 :crystalline solid
- 颜色 :White
- 水溶解性 :Soluble to 100 mM in water
N-ETHYLLIDOCAINE BROMIDE性质、用途与生产工艺
- 生物活性 QX-314 bromide 是一种膜不渗透的钠离子通道永久性电荷阻滞剂。
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靶点
sodium channel
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体外研究
QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro .
QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.
QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death .
QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca 2+ currents are on average < 10% of control amplitude .
QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- .
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体内研究
QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
Animal Model: Male Sprague-Dawley rats (250-290 g) Dosage: 1.6 mg/kg Administration: Intracutaneous injection Result: Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
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