N-ETHYLLIDOCAINE BROMIDE
N-ETHYLLIDOCAINE BROMIDE 性质
| 熔点 | 214-215 °C |
|---|---|
| 储存条件 | Desiccate at RT |
| 溶解度 | 不溶于乙醇；水中≥10.5 mg/mL； ≥25.55 mg/mL，溶于 DMSO |
| 形态 | 结晶固体 |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 100 mM in water |
N-ETHYLLIDOCAINE BROMIDE 用途与合成方法
sodium channel
QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro .
QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.
QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death .
QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca
2+
currents are on average < 10% of control amplitude .
QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- .
QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
| Animal Model: | Male Sprague-Dawley rats (250-290 g) |
| Dosage: | 1.6 mg/kg |
| Administration: | Intracutaneous injection |
| Result: | Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin. |
