磷酸哌喹

生物活性体内研究磷酸哌喹试剂级价格

磷酸哌喹

CAS号:85547-56-4
英文名:4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
中文名:磷酸哌喹
CBNumber:CB02131090
分子式:C29H32Cl2N6.H3PO4
分子量:633.51
MOL File:85547-56-4.mol

磷酸哌喹化学性质

储存条件 :Store at -20°C
溶解度 :DMSO: Insoluble;
形态 :Solid
颜色 :Off-white to light yellow
水溶解性 :Water: 2 mg/mL (3.16 mM)

磷酸哌喹化学药品说明书

磷酸哌喹|药典2005版
磷酸哌喹片|药典2005版

磷酸哌喹性质、用途与生产工艺

生物活性 Piperaquine phosphate 是一种双喹啉抗疟药，可以与青蒿素联用于抗疟研究。

体内研究

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.
Piperaquine (90 mg/kg; a single i.p.) exhibits the t _1/2 , apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.

Animal Model:	Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites
Dosage:	0, 10, 30, 90 mg/kg
Administration:	A single i.p. administration
Result:	The median survival time was 10 days at dose of 10 mg/kg. The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.

Animal Model:	Male Swiss mice (6 weeks old)
Dosage:	90 mg/kg (Pharmacokinetic Analysis)
Administration:	A single i.p. administration
Result:	t _1/2 =17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.