KF31327
- CAS号:220060-39-9
- 英文名:KF31327
- 中文名:KF31327
- CBNumber:CB02104148
- 分子式:C24H28N6OS
- 分子量:448.58
- MOL File:220060-39-9.mol
KF31327性质、用途与生产工艺
- 生物活性 Thioquinapiperifil (KF31327 free base) 是有效的、选择性的、非竞争性的磷酸二酯酶 (PDE-5) (IC50 为 0.074 nM) 的抑制剂，可用于性成熟的研究。
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靶点
PDE5
0.074 nM (IC 50 )
PDE1
380 nM (IC 50 )
PDE2
670 nM (IC 50 )
PDE3
38 nM (IC 50 )
PDE4
800 nM (IC 50 )
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体外研究
Thioquinapiperifil can be found in dietary supplements.
Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation.
Thioquinapiperifil (KF31327 free base) and shows significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil (KF31327)-treated cells is 0.95±0.17 pmol/10 8 cells.
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
