ChemicalBook CAS数据库列表 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
- CAS号:174264-46-1
- 英文名:4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
- 中文名:
- CBNumber:CB01872789
- 分子式:C34H41NO4SSi
- 分子量:587.84414
- MOL File:174264-46-1.mol
4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene化学性质
- 储存条件 :Refrigerator
- 溶解度 :Acetone, Chloroform, Dichloromethane, Ethanol, Methanol
- 形态 :Solid
- 颜色 :Yellow
- CAS 数据库 :174264-46-1
4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene性质、用途与生产工艺
- 生物活性 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) 是一种Raloxifene 与叔丁基二甲基甲硅烷基氯的反应产物。4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 可用于合成 Raloxifene 6-glucuronide。
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体外研究
The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide.
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4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene生产厂家
- 公司名称:Pharmaffiliates Analytics and Synthetics P. Ltd
- 联系电话:--
- 电子邮件:mktg@pharmaffiliates.com
- 国家:印度
- 产品数:6773
- 优势度:58
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