人永生化肝细胞
- CAS号:63555-63-5
- 英文名:C3A (70-77)
- 中文名:人永生化肝细胞
- CBNumber:CB0170671
- 分子式:C35H61N13O10
- 分子量:823.94
- MOL File:63555-63-5.mol
- 密度 :1.44±0.1 g/cm3(Predicted)
- 储存条件 :−20°C
- 溶解度 :Soluble in DMSO
- 酸度系数(pKa) :3.34±0.10(Predicted)
- WGK Germany :3
人永生化肝细胞性质、用途与生产工艺
- 生物活性 C3a (70-77) 是对应于C3a的COOH末端的八肽，表现出C3a的特异性和1至2％的生物活性。
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靶点
Complement system
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体外研究
The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10 -7 M or higher and exceeds 75% at 10 -6 M, irrespective of the stimulus.
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites.
- 公司名称：SIGMA
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- 国家：瑞士
- 产品数：6896
- 优势度：91
