生物活性 体外研究 体内研究 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 试剂级价格
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ChemicalBook  CAS数据库列表  1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

生物活性 体外研究 体内研究 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 试剂级价格
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone,511-26-2,结构式
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
  • CAS号:511-26-2
  • 英文名:1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
  • 中文名:1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
  • CBNumber:CB01260975
  • 分子式:C22H34O2
  • 分子量:330.5
  • MOL File:511-26-2.mol
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone化学性质
  • 熔点 :123.5°
  • 比旋光度 :D18 +18° (c = 1.085 in chloroform)
  • 沸点 :426.6±45.0 °C(Predicted)
  • 密度 :1.04±0.1 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :DMSO: 25 mg/mL (75.64 mM)
  • 形态 :Solid
  • 颜色 :White to off-white

1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone性质、用途与生产工艺

  • 生物活性 MAP4343 是 Pregnenolone 的 3-甲基醚衍生物。MAP4343 在体外与微管相关蛋白 2 (MAP2) 结合，刺激微管蛋白的聚合，增强神经突的延伸并保护神经元免受神经毒性剂的侵害。
  • 体外研究

    MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro.
    MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.
    MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells

  • 体内研究

    MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.
    MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats.
    MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats.

    Animal Model: Adult Sprague-Dawley male rats with spinal cord injury
    Dosage: 12 mg/kg
    Administration: Daily s.c. for 28 days
    Result: Increased the number of animals able to walk with weight-supported plantar steps.
    Showed forelimb-hindlimb coordination at the end of the study.
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone上下游产品信息
上游原料
下游产品
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-107116
  • 产品名称：1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone MAP4343
  • CAS编号：511-26-2
  • 包装：5mg
  • 价格：1000元
  • 更新日期：2024/11/08
  • 产品编号：HY-107116
  • 产品名称：1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone MAP4343
  • CAS编号：511-26-2
  • 包装：10mM * 1mLin DMSO
  • 价格：1100元
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone生产厂家
  • 公司名称：上海传芊化工科技中心
  • 联系电话： 15869524721
  • 电子邮件：3525679403@qq.com
  • 国家：中国
  • 产品数：4325
  • 优势度：58
  • 公司名称：TargetMol中国（陶术生物）
  • 联系电话： 4008200310
  • 电子邮件：marketing@tsbiochem.com
  • 国家：中国
  • 产品数：24644
  • 优势度：58
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